Eosinophil-degranulation products drive a proinflammatory fibroblast phenotype

RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism

BACKGROUND The association of eosinophils with inflammation and tissue remodeling is at least partially due to their release of toxic granule proteins and other mediators, including cytokines. Tissue remodeling and consequent functional defects are affected by activity of connective tissue fibroblasts. Exaggerated fibroblast activation, accumulation and change of phenotype may lead to fibrosis ...

Epithelial Cells Induce Eosinophil Degranulation Respiratory Syncytial Virus-Infected Pulmonary

Ultrastructural characterization and morphometric analysis of human eosinophil degranulation.

Human eosinophil degranulation induced by the calcium ionophore A23187 was examined by transmission and scanning electron microscopy, and morphometric analysis. After incubation with A23187, eosinophil degranulation was characterized by granule movement to the cell periphery and pentalaminar membrane fusion between perigranular and plasma membranes. As adjacent granules fused they became swolle...

Allergen-specific IgG1 and IgG3 through FcRIl Induce Eosinophil Degranulation

Evidence suggests that eosinophils contribute to inflammation in bronchial asthma by releasing chemical mediators and cytotoxic granule proteins. To investigate the mechanism of eosinophil degranulation in asthma, we established an in vitro model of allergen-induced degranulation. We treated tissue culture plates with short ragweed pollen (SRW) extract and sera from either normal donors or SRW-...

Tissue eosinophilia and eosinophil degranulation in Riedel's invasive fibrous thyroiditis.

The etiology of Riedel's invasive fibrous thyroiditis (IFT) has remained obscure. This rare disorder has been confused in the past with the more common fibrous variant of Hashimoto's disease. The typical histological features of IFT, in particular the presence of an invasive fibrosclerotic process in conjunction with a prominent chronic inflammatory infiltrate, suggest that the release of fibro...